Taking Tramadol And Eliquis Together

In our latest question and answer, the pharmacist discusses whether or not it is safe to take Eliquis with tramadol.

May 02, 2018

SMN asked

What are the risks for taking 1 Tramadol 50mg once or twice daily and Eliquis 5mg twice daily?


There are no reported or documented interactions between tramadol and Eliquis. They are generally considered safe to take with one another if indicated.

Eliquis (Apixaban)

Eliquis is anticoagulant medication used for the prevention of stroke and embolism in individuals who have non-valvular atrial fibrillation. Eliquis is dosed twice daily and may be given without regard to meals.

Eliquis should not be used in any patient that has a bleeding condition, is going to be getting a epidural or spinal anesthesia, or has any type of lumbar puncture. If taking Eliquis it is very important that you do not abruptly discontinue the medication. Potential side effects you may experience while taking Eliquis include but are not limited to:

  • Bleeding from nose or lungs
  • Blood in urine
  • Anemia
  • Heavy or abnormal periods
  • Hypotension
  • Rash


Tramadol is a synthetic analog of codeine and is classified as an opioid analgesic. While the majority of analgesic effect is thought to be due to its activity on opioid receptors, it also is thought to increase the neurotransmitter norepinephrine. Tramadol is indicated for use in treating moderate to severe pain.

The dose of tramadol should be slowly titrated to increase tolerability and may be given with or without food. The different forms or extended release tramadol are not dosed the same and should not be interchanged. The orally disintegrating tablets should be dissolved on the tongue not chewed or crushed. Common side effects of tramadol include but are not limited to:

  • Constipation
  • Dizziness
  • Drowsiness
  • Headache
  • Nausea
  • Vertigo
  • Flushing
  • Dyspepsia
  • Agitation


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