How Much Benadryl Does ZzzQuil Contain?

In our latest question and answer, the pharmacist compares how much diphenhydramine is contained in Benadryl and ZzzQuil products.

How Much Benadryl Does ZzzQuil Contain?
Dec 13, 2019

Geno asked

I was told that Benadryl and ZzzQuil are the same, so I just want to know how much Benadryl is in ZzzQuil?

At a glance

  • ZzzQuil Warming Liquid contains 50mg of diphenhydramine per dose (30 mL), which is equivalent to two Benadryl tablets.
  • ZzzQuil LiquiCaps contain 25mg of diphenhydramine per LiquiCap, which is equivalent to one Benadryl tablet.

Answer

ZzzQuil Packaging On Shelf

Hello and thank you for your question!

It is important to remember that Benadryl is a brand name product, which contains the active ingredient diphenhydramine. So, just to rephrase this question, you are asking how much diphenhydramine is contained in ZzzQuil (another brand name product).

ZzzQuil comes in a variety of products (e.g. LiquiCaps, Warming Liquid, PureZzzs, etc...) but I'll focus on the main two, the liquid and capsules, which both contain the exact same active ingredient as Benadryl, which again, is diphenhydramine.

  • ZzzQuil Warming Liquid contains 50mg of diphenhydramine per 30mL (one dose cup).
  • ZzzQuil LiquiCaps contain 25mg of diphenhydramine per LiquiCap.

To put this in perspective, Benadryl contains 25mg of diphenhydramine per tablet. So:

  • Taking one 30mL dose cup of ZzzQuil Warming Liquid would be the same as taking two Benadryl tablets (50 mg diphenhydramine).
  • Taking one ZzzQuil LiquiCap would be the same as taking one Benadryl tablet (25mg of diphenhydramine).

I want to clarify that ZzzQuil and Benadryl are not 'the same thing' as you state in your question, but are two unique drug products produced by different manufacturers. However, they do contain the same active ingredient, diphenhydramine, as discussed above. The inactive ingredients (e.g. the fillers, flavorings, colors, etc...) are different though.

References
  1. Benadryl Manufacturer Website. Benadryl
  2. ZzzQuil Manufacturer Website. Vicks
  3. Diphenhydramine Monograph. PubChem

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