talia asked
Does zantac interact with suboxone? I get sick to my stomach some times and wanted to know what would work. Any other suggestions
At a glance
- There is no known drug interaction between ranitidine and Suboxone.
Answer
There are no known drug interactions between Zantac (ranitidine) and Suboxone (buprenorphine; naloxone). They can safely be taken together.
Zantac Information
Zantac (ranitidine) is classified as an H2 blocker and works by blocking histamine at the H2 receptor.
While classified as an antihistamine, Zantac, as well as other H2 blockers, differ from the antihistamines used for allergies like Benadryl and Claritin, which block histamine at the H1 receptor.
H2 blockers work to reduce acid production by blocking parietal cells from being stimulated to produce acid by histamine.
H2 blocking antihistamines are indicated for the treatment of many conditions resulting from increased acid production in the stomach including:
- Ulcers
- Dyspepsia
- Gastroesophageal reflux disease (GERD)
- Esophagitis
Although H2 blockers are generally used for stomach related issues, evidence suggests they are also beneficial for treating hives.
Suboxone Information
Buprenorphine; naloxone is a combination drug administered sublingually or buccally for the treatment of opiate agonist dependence and pain relief.
- Buprenorphine is a mixed opiate agonist-antagonist.
- Naloxone is an opiate antagonist.
When taken as directed, buprenorphine is responsible for the pharmacological effects of Suboxone. Buprenorphine has a "ceiling" of effect, and therefore, the danger of overdose, abuse, and toxicity with it may be less than with full opioid agonists.
The low-dose naloxone, an opiate antagonist, has no effect when taken sublingually or buccally. If abused and given via injection, it can precipitate withdrawal and therefore its addition to Suboxone mitigates abuse potential.
Suboxone Administration
- Prior to administration, it may be beneficial to drink water to moisten the inside of the mouth, which helps the films dissolve more easily.
- Place film under the tongue and allow to completely dissolve. Do not move the film once placed.
Nausea, as you mentioned in your inquiry, is a fairly common side effect of Suboxone, occurring in 15% of individuals taking the medication according to the prescribing information.
If you are experiencing nausea after taking Suboxone, it may help to take an antacid or an H2 blocker (like Zantac) prior to administration. In addition, it may help to administer Suboxone on a full stomach. Taking on an empty stomach may increase the incidence of nausea.
