Prolonged use should be avoided.
Can you take Advil with prednisone?
Use together can increase the risk of adverse GI effects and alter electrolyte/fluid balance.
Additionally, Advil can mask symptoms of infection, which you could be at an increased risk of while taking prednisone.
Short-term use of both is fairly common, and can be used in certain situations.
However, prolonged use should be avoided as this increases the risk of adverse reactions (as mentioned above)
If you are taking prednisone, be sure to ask your doctor if Advil is appropriate for you in your medical situation.
Prednisone is a corticosteroid while Advil (ibuprofen) is classified as a NSAID (non-steroidal anti-inflammatory drug).
Multiple studies have shown that concomitant use of corticosteroids (like prednisone) and NSAIDs can have a variety of adverse effects, including:
If prednisone and Advil are used together for extended period of time, it is sometimes recommended to periodically monitor potassium levels in the body as hypokalemia (low potassium) has commonly been reported.
It is important to note that prednisone can weaken the immune system, especially with high doses or long term use. NSAIDs, like Advil, can mask fever, pain, swelling and other signs and symptoms of an infection. The issue is that a potential infection may not be appropriately treated.
Lastly, the Beers criteria recommends that the combination of NSAIDs and corticosteroids be avoided. If the combination is necessary and cannot be avoided, it is recommend to also use some sort of gastrointestinal protection.
As stated previously, short term use of both medications has been used safely, but they should only be used together if recommended by your doctor.