Taking Cheratussin With Sinex

In our latest question and answer, the pharmacist discusses whether or not Sinex can safely be taken with Cheratussin.

Feb 20, 2018

Brendan asked

Can I take cheratussin with Sinex night time? I’m 6’2” and 250 lbs and I’m having trouble sleeping because of sinus pressure and cough/chest congestion.


Sinex comes in multiple formulations (as discussed below). Most are safe to take with Cheratussin (guaifenesin/codeine) but you do want to avoid nighttime Sinex formulations due to the risk of additive sedative effects from both. Below are the common Sinex formulations along with a note regarding whether or not they are safe to take with Cheratussin.

Sinex Formulations With Cheratussin

Sinex Daytime Liquicaps

  • Acetaminophen (analgesic)
  • Phenylephrine (nasal decongestant)

Sinex Daytime is safe to take with Cheratussin and there is no interaction between the two.

Sinex Nighttime Liquicaps

  • Acetaminophen (analgesic)
  • Phenylephrine (nasal decongestant)
  • Doxylamine (sedating antihistamine)

Sinex Nighttime should not be taken with Cheratussin. Sinex Nighttime contains doxylamine, a sedating second generation antihistamine. Combining both could cause excess sedation and increase the risk of side effects such as confusion, dry mouth, dry eyes and constipation.

Sinex Nasal Spray

  • Oxymetazoline (nasal decongestant)

Cheratussin is safe to take with most Sinex products. It should not however be taken with Sinex Nighttime.


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