How Long Does One Dose Of Amoxicillin Stay In Your System?

In our latest question and answer, the pharmacist discusses how long one dose of amoxicillin lasts in your system.

Jul 31, 2018

Brian asked

How long does amoxicillin stay in your system?


We have written a few articles on this subject, which can be found here:

Below are some highlights from that article:

  • Amoxicillin has a short half-life relative to other drugs, around 1 to 1.5 hours. 'Half-life' refers to the time it takes our bodies to metabolize 50% of a drug.
  • Most of your amoxicillin dose will be eliminated within 12 hours (this is why it needs to be dosed 2-3 times daily). More than 60% will be eliminated via the urine 6 hours after your last dose.
  • Elimination time can be prolonged in patients with kidney disease. There are reports that the half-life of amoxicillin is extended to over 12 hours in those with end-stage kidney disease.
  • Amoxicillin will last longer in pediatric patients less than 12 weeks of age due to incompletely developed renal function.


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