Drug Interaction Between Buspirone, Paroxetine, Cyclobenzaprine & Naproxen

In this article, we answer a reader question regarding interactions between various drugs.

Oct 25, 2017

Toots asked

Can I take naproxen and cyclobenzaprine with paroxetine and buspirone? Thank you for your help. 


There a few things to be aware of and concerned about regarding this combination drugs. Having said that, all of these medications have been used in combination with one another when indicated, with no side effects, it just depends on the individual. It is important that your doctor and pharmacy are aware of the combination of drugs so you can be monitored appropriately. They can also check for interactions between others drugs you may be taking. Below is a list of the possible interactions between naproxen, cyclobenzaprine, paroxetine and buspirone.

Paroxetine And Cyclobenzaprine 

Paroxetine may increase risk for additive serotonin-related side effects with cyclobenzaprine . While very rare, the combination of these two drugs increases the risk of serotonin syndrome. Symptoms of serotonin syndrome include agitation, elevated body temperature, tremors, sweating and gastrointestinal effects. If untreated, it could lead to seizures. While serotonin syndrome is uncommon, it is good to be aware of the symptoms just in case. There are a variety of prescription drug that affect serotonin so it is important to be aware of which ones do.

Naproxen And Paroxetine

Both drugs can thin the blood, possibly increasing the risk of clotting problems. Typically the combination is OK to use in practice as long as there are not any preexisting bleeding conditions and you are not taking any blood thinner medications.

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