Benadryl With Cymbalta Drug Interaction

In our latest question and answer, the pharmacist discusses whether or not there is an interaction between Cymbalta and Benadryl.

Jun 21, 2018

Tetyana asked

Can I take bendaryl and Cymbalta (60mg)?


Benadryl and Cymbalta do not have any drug interactions and may be taken together if symptoms dictate. However, they both have the potential to cause side effects such as drowsiness so caution should be observed if these effects are present.

What Is Cymbalta (Duloxetine)?

Cymbalta is a serotonin-norepinephrine reuptake inhibitor antidepressant most commonly used to treat depression, anxiety, and nerve pain. Cymbalta should be taken whole and may be taken with or without food. Common side effects associated with taking Cymbalta include but are not limited to:

  • Drowisiness
  • Dizziness
  • Headache
  • Nausea
  • Weight loss

What Is Benadryl (Diphenhydramine)?

Benadrylis a sedating antihistamine used most commonly for the treatment of allergic reactions, seasonal allergies, symptoms associated with the common cold and insomnia. Benadryl may be taken without regard to meals. commonly reported side effects associated with taking Benadryl include but are not limited to:

  • Drowsiness
  • Dizziness
  • Fatigue
  • Dry mouth

Ready for a more personal experience with your meds?