Does Shingrix Contain Soy?

Soy bean allergens are not knowingly used in Shingrix, the preferred shingles vaccine. However, analytical testing has not been done to ensure a soy-free product.

Does Shingrix Contain Soy?
Nov 01, 2018

Cat asked

Does Shingrix contain any soy ingredients? Is it safe for those who have a soy allergy?

At a glance

  • Soy beans and associated allergens (e.g. profilin, beta-conglycinin, glycinin, seed biotinylated protein, 2S albumin, and lectin/agglutinin) are not knowingly added or used in the manufacturing process of the Shingrix vaccine.
  • However, analytical testing to detect the presence of soy and related allergens in Shingrix has not been done.


Soy Bean Title

Allergies and sensitivities are a major concern and need to be taken into account in all situations. It can sometimes to difficult to discern whether or not a particular medication is safe, as a complete list of ingredients is not always accessible.

When it comes to Shingrix, the recommended vaccine for shingles, we posted an article recently detailing the complete ingredient list:

  • 50 mcg recombinant gE antigen
  • 50 mcg MPL
  • 50mcg QS-21
  • 20 mg sucrose (as a stabilizer)
  • 4.385 mg sodium chloride
  • 1 mg DOPC
  • 0.54 mg potassium dihydrogen phosphate
  • 0.25 mg cholesterol
  • 0.160 mg sodium dihydrogen phosphate dihydrate
  • 0.15 mg disodium phosphate anhydrous
  • 0.116 mg dipotassium phosphate
  • 0.08 mg polysorbate 80
  • Host cell proteins (≤3.0% DNA (≤2.1 picograms) from the manufacturing process

Soy In Shingrix

The prescribing information for Shingrix, unfortunately, does not list any information regarding soy and whether or not it is safe for those with a soy allergy.

We reached out to GSK (GlaxoSmithKline) for additional information regarding the soy content of Shingrix. We received the following response:

  1. Personal Communication: GSK On November 1, 2018
  2. Ask the Experts. NEJM
  3. Shingrix Recommendations. CDC

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