Does Shingrix Contain Neomycin?

In our latest question and answer, the pharmacist discusses whether or not Shingrix contains neomycin.

Mar 31, 2018

John asked

Does Shingrix Vaccine contain neomycin as the Zostrix vaccine does contain. I have Neomycin allergy by skin testing. Thanks


The shingles (i.e. herpes zoster) vaccine Shingrix does not contain neomycin. This is good news for those with a neomycin allergy as the other shingles vaccine, Zostavax, contains neomycin.

As Shingrix does not contain neomycin, it may be administered to those with a neomycin allergy.

Shingrix Ingredients

Each 0.5 ml dose of Shingrix contains the following ingredients:

  • Recombinant gE antigen (50 mcg)
  • Monophosphoryl lipid A (50 mcg)
  • QS-21 50 mcg (saponin purified from plant extract Quillaja saponaria)
  • Sucrose 20 mg
  • Sodium chloride 4.385 mg
  • DOPC (dioleoyl phosphatidylcholine) 1 mg 
  • Potassium dihydrogen phosphate 0.54 mg
  • Cholesterol 0.25 mg 
  • Sodium dihydrogen 0.160 mg 
  • Phosphate dihydrate
  • Disodium phosphate anhydrous 0.15 mg 
  • Dipotassium phosphate 0.116 mg 
  • Polysorbate 80 0.08 mg 
  • Residual amounts of host cell proteins (≤3.0%) and DNA (≤2.1 picograms) from the manufacturing process.

In addition, the the vial stoppers are not made with natural rubber latex.

  • Shingrix does not contain neomycin and may be administered to those with a neomycin allergy.

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