randi asked
I am taking methadone. I also take metoprolol tartrate 25 mg twice a day. I'm about to take Mavyret for my hepatitis C but I want to make sure it's okay with the methadone and metoprolol tartrate?
At a glance
- Metoprolol and methadone can both lower blood pressure. Additionally, Mavyret can inhibit P-glycoprotein (P-gp), which could decrease methadone excretion, increasing drug concentrations in the body.
Answer
Metoprolol, Mavyret, and methadone are considered safe to take together, but there are a few potential interactions to be aware of.
Low Blood Pressure With Metoprolol and Methadone
Methadone can lower blood pressure in some individuals.
Since metoprolol also lowers blood pressure, there is a chance that taking methadone with it can have additive effects.
Methadone specifically is known to cause 'orthostatic hypotension', which is a significant drop in blood pressure when going from a sitting or lying down position to standing. This drop in blood pressure can cause dizziness, lightheadedness and can increase the risk of falls.
The prescribing information for methadone states the following:
References
- Elsevier ClinicalKey: Methadone Monograph
- Methadone Prescribing Information
- Methadone: a review of its pharmacokinetic/pharmacodynamic properties. PubMed
- Mavyret Prescribing Information
- Role of P-glycoprotein in pharmacokinetics: clinical implications. PubMed
