Why Should I Take Lipitor (Atorvastatin) At Night?​

Lipitor (Atorvastatin) is a "statin" medication that belongs to a class of drugs known as HMG-CoA Reductase Inhibitors. These drugs lower cholesterol and improve cardiovascular outcomes by decreasing the amount of cholesterol our body produces as well as reducing inflammation in blood vessels. We recently received a question regarding whether or not you need to take Lipitor at night/bedtime to get the best results.

Why Should I Take Lipitor (Atorvastatin) At Night?​
Oct 03, 2017

Salaci asked

Why do the directions on my Lipitor bottle say to take late in the evening?

Answer

Female PharmacistIt is a common misconception that Lipitor (Atorvastatin) needs to be taken in the evening or at bedtime. While this is true of some medications in the "statin" class, this is not the case for Lipitor (Atorvastatin). It may be taken anytime during the day, as long as you take it at the same time consistently. 

Cholesterol is​ an extremely important component of all our cells and is also a precursor to a variety of hormones. While we do get cholesterol from our diet, much of it is actually produced by our own bodies. There have been numerous studies showing that the peak of cholesterol production occurs while we are sleeping. Below, we have posted a graph showing the peaks and troughs of cholesterol production at various times throughout the day. While the graph is somewhat noisy, we can clearly see cholesterol production peaks late evening/early morning.

Taking Lipitor At Night

Since cholesterol production is higher in the evening, the general recommendation used to be to take statin medications in the evening to provide maximum effectiveness. Over time, studies have shown that all statin medication have different properties. The important property to look at in terms of appropriate dosing time is "half-life". The half life of a drug will factor into how long it takes for a medication to be metabolized and eliminated from the body. With consistent dosing, statins with a long half life allow them to maintain effective levels in the body over a 24 hour period, negating the need for specific nighttime dosing. Conversely, statins with a short half life should be dosed in the evening for maximum effectiveness. The chart below lists some common statin medications and the recommended time of dosing.
Cholesterol Dosing Chart
In summary, each statin medication has a different time of dosing recommendation that is dependent on their half life. Lipitor (Atorvastatin) has a relatively long half-life and therefore does not need to be dosed in the evening or at bedtime for it to be effective. 

Ready for a more personal experience with your meds?