When Can You Drink Alcohol After Taking Flexeril?

In our latest question and answer, the pharmacist discusses when it is safe to drink alcohol after taking the muscle relaxant Flexeril (cyclobenzaprine).

When Can You Drink Alcohol After Taking Flexeril?
Aug 30, 2020

Bubby asked

How long after taking cyclobenzaprine can someone consume alcohol?

At a glance

  • Cyclobenzaprine lasts quite a while in your system, longer than 24 hours.
  • It is generally recommended to avoid alcohol while taking cyclobenzaprine.
  • If you do decide to drink, I would recommend waiting at least 24 hours and drinking less than your might normally.


Thanks for your question!

Cyclobenzaprine actually lasts quite a long time in your system. The reported half-life of the drug, the amount of time that it takes for your body to metabolize half of the medication and remove it from your body, ranges between 8-37 hours in most adults.

Now, the half-life is It’s dependent on several factors such as your genetics, age, and your liver function. The elderly and folks with impaired liver function tend to metabolize it slower. If we assume that you metabolize cyclobenzaprine quickly, even 24 hours after a single 10mg dose, at least 1.25mg of cyclobenzaprine would still be in your system.

Per the labeling information:

“Cyclobenzaprine, especially when used with alcohol or other CNS depressants, may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle.”

Since it does last a while in your system, I would recommend waiting at least 24 hours after your last dose of cyclobenzaprine before you have a drink. Drinking while on cyclobenzaprine is discouraged, but not contraindicated. If you do decide to drink, remember that alcohol and cyclobenzaprine have a similar effect on your central nervous system. Since you might still have cyclobenzaprine in your system, you will feel the effects of the alcohol after a fewer number of drinks and more intensely than drinking with no cyclobenzaprine in your system. 

I hope I was able to help. Feel free to write us back in the future.

Ready for a more personal experience with your meds?