Interaction Between Tri-Sprintec With Melatonin

There is a potential minor interaction.

Interaction Between Tri-Sprintec With Melatonin
Nov 19, 2018

Sadie asked

I’ve been having trouble sleeping and I would like to try taking melatonin. I take the birth control Tri-Sprintec. Is it safe to take both or are there interactions?

At a glance

  • Melatonin levels can potentially be increased when taken with estrogen containing birth control pills.
  • Estrogens can inhibit CYP1A1 and CYP1A2 enzymes, which are responsible for melatonin metabolism.


Looking At BC Pill

There is a minor drug interaction between melatonin and Tri-Sprintec.

Studies show that the estrogen in Tri-Sprintec (Ethinyl Estradiol) can inhibit the metabolism of melatonin, which could increase concentrations of endogenous and supplemental melatonin in the blood.

This interaction is thought to be mild at best and generally doesn't result in any clinically significant symptoms.

Interaction Info

Tri-Sprintec can inhibit certain CYP metabolizing enzymes in the body, notably CYP1A1 and CYP1A2.

Melatonin is metabolized by these enzymes. Inhibition of these enzymes can decrease the metabolism of melatonin, theoretically increasing the effects and adverse reactions of melatonin use.

For example, supplementing with melatonin at night while taking Tri-Sprintec could cause excess sedation.

As a general precaution, care should be exercised when using melatonin in those taking estrogens (e.g. from combined oral contraceptives).

This potential interaction isn't thought to be clinically significant for most individuals. Nevertheless, it is important to be aware of.

  1. Acute effects of bright light and caffeine on nighttime melatonin and temperature levels in women taking and not taking oral contraceptives. PubMed
  2. Further assessment of 17alpha-ethinyl estradiol as an inhibitor of different human cytochrome P450 forms in vitrp. PubMed

Ready for a more personal experience with your meds?