The pharmacist discusses whether or not there is a potential interaction between St. John's wort and ibuprofen.
Answered By: Dr. Brian Staiger Pharm.D
Dec 13, 2018
I am wondering if it is safe to take St. John's wort with ibuprofen?
At a glance
Although studies show that St. John's Wort could potentially affect the metabolism of ibuprofen, there have been no clinically significant drug interactions reported, even in studies in which both were given together.
While it may work to help you fall asleep for a few days, long-term use of Benadryl as a sleep-aid likely isn't effective and is associated with several side effects like next-day drowsiness. Additionally, the long-term use of drugs like Benadryl in those 65 years old and over is linked with an increased risk of dementia.
Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of the Q+A website PharmacistAnswers.com. He graduated from the University At Buffalo with a Doctor of Pharmacy degree in 2010.
He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs.
Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours!