Taking Methylprednisolone With Advil (Ibuprofen) Or Aleve (Naproxen)

In our latest question and answer, the pharmacist discusses the use of NSAIDs like ibuprofen and naproxen with Medrol (methylprednisolone).

Jun 21, 2018

JRD asked

Just finished a 5 day course of 4mg methylprednisolone last night. How long before I can take Advil or Aleve?


While they should not be taken at the same time due to possible serious additive GI effects, Advil (ibuprofen) or Aleve (naproxen) may be taken after a normal course of methylprednisolone has been completed.

In general, you should wait between 6 to 8 hours before taking Advil or Aleve after finishing methylprednisolone to avoid additive GI side effects. It should be noted that methylprednisolone does have a long half-life (around 18-36) hours and will last in the body for 4 to 7 days after finishing your course of therapy. Nevertheless, peak effects of methylprednisolone occur within a few hours after taking by mouth and the risk of additive GI effects significantly decreases a few hours after your last dose.

About Advil And Aleve

Advil (Ibuprofen) and Aleve (naproxen) are non-steroidal anti-inflammatory drugs (NSAIDs). NSAiDs are most commonly used to treat pain, arthritis, and inflammation. NSAIDs should be administered with food or milk to help prevent gastrointestinal irritation. Common side effects associated with taking NSAIDs include but are not limited to:

  • Dyspepsia
  • Heartburn
  • Vomiting
  • Diarrhea

About Methylprednisolone

Methylprednisolone is a corticosteroid used to treat a wide variety of conditions. It can be used for its anti-inflammatory, hormone modifying, and/or immunosuppressive effects. In general methylprednisolone should be given with a meal and in the morning although more specific dosing schedules are often given when using an oral steroid. Common side effects associated with taking methylprednisolone include but are not limited to:

  • Anxiety
  • GI irritation
  • Insomnia
  • Diarrhea
  • Hypertension

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