Taking Concerta With Contrave (Naltrexone/Bupropion)

In our latest question and answer, the pharmacist discusses the potential interaction between Concerta and Contrave.

May 09, 2018

Vvazque asked

Can concerta and contrave interact together?


There is an interaction that has been identified between Concerta (methylphenidate) and Contrave (naltrexone/bupriopion hydrochloride). The interaction is an additive effect that will increase the risk of seizures. It is for this reason that caution is advised when combining these medications.


Concerta is a central nervous stimulant that is used to treat attention deficit hyperactive disorder (ADHD). It has been found that stimulants may lower the threshold to have a seizure.

Common side effects include:

  • Nervousness
  • Insomnia
  • Anorexia
  • Nausea
  • Headache
  • Dizziness
  • Visual Disturbance
  • Blood pressure and heart rate changes

Do not crush or chew the tablets, but the capsules may be opened and sprinkled into applesauce if you have trouble swallowing tablets.


Contrave is a combination medication of an opioid antagonist, naltrexone, and an antidepressant, bupropion hydrochloride. Contrave is used, along with diet and excercise, for chronic weight management. The medication bupropion  can cause seizures and appears to be related to the dose that is being taken. 

Common side effects include:

  • Nausea and vomiting
  • Constipation
  • Headache
  • Dizziness
  • Insomnia
  • Dry Mouth
  • Increased blood pressure
  • Anxiety

Do not take Contrave with a high in fat meal. When taking an antidepressant no matter the treatment it is important to monitor for mood changes or depression.

Interaction Between Concerta And Contrave

Knowing that both medications can increase the risk of seizures you should use caution when taking Concerta along with Contrave. This risk is increased further in patients that have a history of seizures. If you have a seizure while taking Contrave stop taking the medication. Talk with your doctor to determine what your risk is for seizures when taking Concerta and Contrave.

Concerta Package insert, Contrave package insert

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