Taking Benadryl With Dayquil

In this article, our pharmacist discusses whether or not you can take Benadryl (Diphenhydramine) with Dayquil.

Nov 05, 2017

Teri asked

Can I take Benadryl and Dayquil together?


Yes, you can take Benadryl (diphenhydramine) and Dayquil together as they do not interact. However, most people take Dayquil to alleviate cough/cold symptoms without sedation and Benadryl would defeat that purpose.

Dayquil contains:

  • Acetaminophen - Pain reliever/fever reducer
  • Dextromethorphan - Cough suppressant
  • Phenylephrine - Nasal decongestant

None of the above ingredients cause sedation and provide effective relief of many cough/cold symptoms. Dayquil is a good option for those who need to be active after administration or operate heavy machinery. 

Benadryl (diphenhydramine) is a sedating antihistamine, that typically produces drowsiness within 30 minutes and can last 4-8 hours.

If you are looking for the benefits of an antihistamine in addition to taking Dayquil, we recommend trying the following antihistamines as they will not cause sedation:

  • Claritin
  • Allegra

If you are looking to for help sleeping while taking Dayquil, try 'Nyquil Severe' instead, as it combines all of the ingredients of Dayquil with the sedating antihistamine doxylamine.


Ready for a more personal experience with your meds?