Taking Benadryl With Dayquil

In this article, our pharmacist discusses whether or not you can take Benadryl (Diphenhydramine) with Dayquil.

Nov 05, 2017

Teri asked

Can I take Benadryl and Dayquil together?

Answer

Yes, you can take Benadryl (diphenhydramine) and Dayquil together as they do not interact. However, most people take Dayquil to alleviate cough/cold symptoms without sedation and Benadryl would defeat that purpose.

Dayquil contains:

  • Acetaminophen - Pain reliever/fever reducer
  • Dextromethorphan - Cough suppressant
  • Phenylephrine - Nasal decongestant

None of the above ingredients cause sedation and provide effective relief of many cough/cold symptoms. Dayquil is a good option for those who need to be active after administration or operate heavy machinery. 

Benadryl (diphenhydramine) is a sedating antihistamine, that typically produces drowsiness within 30 minutes and can last 4-8 hours.

If you are looking for the benefits of an antihistamine in addition to taking Dayquil, we recommend trying the following antihistamines as they will not cause sedation:

  • Claritin
  • Allegra

If you are looking to for help sleeping while taking Dayquil, try 'Nyquil Severe' instead, as it combines all of the ingredients of Dayquil with the sedating antihistamine doxylamine.

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