In this article, our pharmacist discusses whether or not you can take Benadryl (Diphenhydramine) with Dayquil.
Can I take Benadryl and Dayquil together?
Yes, you can take Benadryl (diphenhydramine) and Dayquil together as they do not interact. However, most people take Dayquil to alleviate cough/cold symptoms without sedation and Benadryl would defeat that purpose.
None of the above ingredients cause sedation and provide effective relief of many cough/cold symptoms. Dayquil is a good option for those who need to be active after administration or operate heavy machinery.
Benadryl (diphenhydramine) is a sedating antihistamine, that typically produces drowsiness within 30 minutes and can last 4-8 hours.
If you are looking for the benefits of an antihistamine in addition to taking Dayquil, we recommend trying the following antihistamines as they will not cause sedation:
If you are looking to for help sleeping while taking Dayquil, try 'Nyquil Severe' instead, as it combines all of the ingredients of Dayquil with the sedating antihistamine doxylamine.