Junel Fe With Imipramine And Vesicare

We answer our latest drug interaction question.

Aug 10, 2018

Gella asked

If I am taking Junel Fe 1/20 as birth control and was prescribed a low dose (10mg) of Tofranil (imipramine) will that make my birth control less effective? Also I was prescribed Vesicare 10mg daily, will that effect the birth control?

At a glance

  • Tofranil and Vesicare should not decrease the effectiveness of your birth control pills (Junel).
  • Tofranil and Vesicare however, may have additive side effects, but in most cases, will be generally mild.


There is no interaction between Junel Fe and Tofranil (imipramine) or Vesicare (solifenacin). Taking them will not decrease the effectiveness of your birth control pills.

There is, however, a moderate interaction between Tofranil (imipramine) and Vesicare (solifenacin).

Tofranil With Vesicare

Both imipramine and Vesicare (solifenacin) have what is known as 'anticholinergic effects', which could be additive when used together. These effects include:

  • Dizziness
  • Sedation
  • Fainting or falling spells
  • Palpitations
  • Shortness of breath
  • Difficulty with urination
  • Dry mouth
  • Changes in vision

The risk of these side effects in your situation is relatively low for two reasons:

  • You are taking a small dose of Tofranil (imipramine), and the side effects of the drug are (mostly) dose-dependent.
  • Vesicare is selective for receptors in the bladder and has minimal effects elsewhere in the body.

Nevertheless, they are good to know about so you can be aware of what to look for.

  1. Comparison of muscarinic receptor selectivity of solifenacin and oxybutynin in the bladder and submandibular gland of muscarinic receptor knockout mice. PubMed
  2. Managing Anticholinergic Side Effects. PubMed
  3. Tofranil Prescribing Information. AccessFDA
  4. Vesicare Prescribing Information. Astellas

Ready for a more personal experience with your meds?