Is Sudafed Safe To Take With Your Allergy Medicine?

In our latest question and answer, the pharmacist discusses whether or not Sudafed (pseudoephedrine) can safely be taken with allergy medicine.

Is Sudafed Safe To Take With Your Allergy Medicine?
Jun 19, 2018

Jenny asked

Can I take a Sudafed along with a 24 hour allergy pill?


Nasal CongestionSudafed does not interact with most allergy medications and considered safe to take with 24 hour antihistamines, including:

  • Benadryl (diphenhydramine)
  • Claritin (loratadine)
  • Zyrtec (cetirizine)
  • Allegra (fexofenadine)
  • Xyzal (Levocetirizine)
  • Chlor-Trimeton (chlorpheniramine)
  • Tavist (clemastine)

It is very common to take both an antihistamine and Sudafed for allergy symptoms. In fact, there are many combination products available that contain both in one dose. These include:

  • Claritin-D (loratadine and pseudoephedrine)
  • Zyrtec-D (cetirizine and pseudoephedrine)
  • Allegra-D (fexofenadine and pseudoephedrine)

While antihistamines may reduce the nasal and sinus symptoms that result due to allergies, they may not completely eliminate them. Sudafed works via a different mechanism (vasoconstriction) and can further help to reduce congestion and sinus pressure.

Ready for a more personal experience with your meds?