ajammer asked
I know that SARMS are debatable, but if someone was taking 100mg of sertraline, would 10mg of osterine and 10mg of ligandrol cause issues?
At a glance
- Ostarine and Ligandrol are selective androgen receptor modulators (SARMs).
- Due to their investigational nature, there isn’t a lot of information out there about the potential for drug interactions with ostarine and ligandrol.
- At least one study suggests the potential for drug interactions with ostarine is low. However, I still don't recommend using ostarine and ligandrol with other prescription medications. Both drugs are not FDA approved, so we don't know if they’re safe and effective yet. Furthermore, the only way to obtain these drugs, outside of clinical trials, is sort of a black market. This market is unregulated, so the source of the drug could be questionable.
Answer
Hi, great question. As you alluded to in your question, Ostarine and Ligandrol are both selective androgen receptor modulators (SARMs). These drugs stimulate androgen receptors, similar to testosterone, but with greater selectivity for receptors in muscle and bone tissue.
The general idea with this class of drugs is that by targetting androgen receptors in certain tissues (muscle and bone) they’ll be able to avoid unwanted side effects that are produced by stimulating androgen receptors in other tissues.
SARMs can stimulate muscle growth and are listed on the World Anti-Doping Agency’s list of prohibited (performance-enhancing) substances.
Unfortunately, there’s just not enough information available on these drugs to give you a definitive yes or no answer. Because these drugs are investigational (still in clinical trials), there is a paucity of data available about them.
Particularly, there is little information available about their metabolism which can help identify the risk for drug interactions. I couldn’t find anything on lingrandrol, but I found out that ostarine is being studied under the name “enobosarm”. I was able to find one study that reviewed the potential for drug interactions with enobosarm (ostarine), and the study concluded that enobosarm (ostarine) poses a low risk for drug interactions.
However, I still don't recommend using ostarine and ligandrol with other prescription medications. Both drugs are not FDA approved, so we don't know if they're safe and effective.
Furthermore, the only way to obtain these drugs, outside of clinical trials, is sort of a black market. This means they're unregulated, so the source of the drug could be questionable. Problems with contamination and mislabeling are common in these situations and can definitely impact the safety profile of the drug(s). In fact, a study published in JAMA found that out of 44 supplements marketed as SARMs online, only 52% actually contained a substance that was considered a SARM and 59% had mislabeled dosages.
So back to your question of would this cause any issues with sertraline therapy? Probably not, but we just don't know enough about these drugs yet. I don't recommend using SARMs because of the risk of contamination and mislabeling that could lead to safety issues including drug interactions. I hope this helps.
References
- World Anti-Doping Agency, Prohibited Substances
- Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet, JAMA
