Is it safe to take DayQuil with a Z-Pak?
At a glance
- Azithromycin has no known interaction with DayQuil or DayQuil Severe.
Yes, it is safe to take DayQuil and a Z-Pak (azithromycin) together. There is no known interaction between the two.
It is important to remember that DayQuil is a combination ingredient product, and contains multiple drugs. All must be considered when discussing whether or not there are interactions.
Fortunately, none of the ingredients in DayQuil interact with a Z-Pak.
The ingredients in DayQuil are as follows:
DayQuil also comes in a 'severe' formula and is known as DayQuil Severe. It contains one additional ingredient:
Just like DayQuil, DayQuil Severe doesn't interact with a Z-Pak.
In fact, A Z-Pak is safe to take with most over the counter medications.
The only ones you should avoid are the following:
- Loperamide (Imodium)
I will touch on each of these briefly below.
Anything over that contains aluminum or magnesium (e.g. Gaviscon, Mylanta) should not be taken at the same take as a Z-Pak since they can decrease the absorption of the antibiotic, which may make it less effective.
The prescribing information for azithromycin states this specifically:
Patients should also be cautioned not to take aluminum- and magnesium-containing antacids and azithromycin simultaneously.
Loperamide, the active ingredient in Imodium-AD, should generally not be taken with a Z-Pak unless directed by your doctor.
Both loperamide (in high doses) and azithromycin are associated with cardiac side effects like QT prolongation.