Benadryl and alcohol. Safe?
Benadryl and Alcohol both act to depress your central nervous system and should not be taken together. Taking both Benadryl and consuming alcohol puts you at risk for potentially serious side effects. These side effects include:
Ideally, alcohol (ethanol) consumption of any kind should be avoided when taking Benadryl. This includes alcoholic beverages (e.g. beer, wine, and spirits) as well as alcohol that may be contained in other medications or food.
Benadryl (diphenhydramine) is a sedating antihistamine used most commonly for the treatment of allergic reactions, seasonal allergies, symptoms associated with the common cold and insomnia. Benadryl crosses the blood brain barrier and depresses the central nervous system, with effects being pronounced if mixed with additional CNS depressants, (such as alcohol).