Interaction Between Naproxen And Bupropion

In our latest question and answer, the pharmacist discusses interactions between several drugs including bupropion and naproxen.

Apr 15, 2018

Kaw asked

I take Synthroid 50mcg, phentermine 37.5mg, bupropion 150mg and escitalopram 10mg.  I’ve injured my ribs. I have Skelaxin and naproxen in my medicine cabinet.... Is it safe to take either?


There is a potential interaction between naproxen (brand names Aleve or Naprosyn) and bupropion (brand name Wellbutrin). We discuss your medication list below and the potential interaction.

  • Synthroid (levothyroxine) is a synthetic T4 hormone used in the treatment of hypothyroidism.
  • Phentermine is a sympathomimetic indicated for the treatment of obesity.
  • Bupropion inhibits the re-uptake of dopamine and norepinephrine. It is indicated most commonly for the treatment of depression and for smoking cessation.
  • Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) most commonly used for the treatment of depression and anxiety.
  • Skelaxin (metaxalone) is a central nervous system depressant indicated for the treatment of musculoskeletal pain.
  • Naproxen is a non-steroidal anti-inflammatory drug (NSAID) commonly used to treat pain and arthritis. 

Interaction Between Naproxen And Bupropion

Taking both bupropion and naproxen together can cause an increased risk for gastrointestinal bleeding

Bupropion alone can cause a decrease in platelet effectiveness which leads to a decrease in your bodies ability to clot. Naproxen causes a decrease in the effectiveness of your gastric mucus ability to protect your gastrointestinal tract. The additive effects of both of these medications can greatly increase your risk for a gastrointestinal bleed. 

There are no other documented drug interactions between either naproxen or Skelaxin with Synthroid, phentermine, bupropion and escitalopram. 

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