Is there a safe amount of grapefruit to consume if I'm taking atorvastatin? I'm interested specifically in Spindrift grapefruit sparkling water, which contains 10% grapefruit juice (so 1.2 ounces per can). Thank you.
It has been fairly well documented that grapefruit juice can interact with several drugs, including Lipitor (atorvastatin), a 'statin' medication used to lower cholesterol.
However, how much grapefruit juice one needs to consume to produce a clinically significant drug interaction isn't entirely known.
Several sources report eating as little as one grapefruit can cause issues. In terms of the actual juice, some studies have shown that less than one cup (~240 mL) of 100% grapefruit juice can cause an interaction.
Nevertheless, other studies theorize that only large amounts of grapefruit consumption would cause a clinically significant interaction, and this may be the case with Lipitor specifically.
The FDA-approved prescribing information for Lipitor does warn about a grapefruit juice interaction, but only when consuming very large amounts (1.2 liters of juice!):