Does NyQuil Contain Benadryl?

In our latest question and answer, the pharmacist discusses whether or not NyQuil contains Benadryl (diphenhydramine).

Question

Does NyQuil contain Benadryl?

Asked by Dwight On Dec 27, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published Dec 27, 2022
Last updated Apr 18, 2024

Key points

  • NyQuil does not contain Benadryl (diphenhydramine). It does contain a similar sedating antihistamine however, doxylamine.

Answer

No, NyQuil does not contain Benadryl (diphenhydramine).

NyQuil contains the following medications:

  • Acetaminophen: An analgesic used for the treatment of fever, headache, aches, and pains.
  • Dextromethorphan: An antitussive agent to help control cough.
  • Doxylamine: A first-generation antihistamine that is commonly used as a sleeping agent due to its side effect of sedation or drowsiness.

Benadryl (diphenhydramine) is also a first-generation antihistamine that can cause sedation or drowsiness. It is considered to be in the same class of drugs as the doxylamine that is found in NyQuil.  Benadryl can also be used as a short-term sleeping aid, but it is also commonly used to treat allergies, allergic reactions, and itching.  Since Benadryl and NyQuil both contain antihistamines, they should not be taken together.  There is an increased risk of the side effects of sedation, drowsiness, confusion, coordination problems, respiratory depression (breathing problems), and dizziness.

Final Words

As stated before, NyQuil does not contain Benadryl (diphenhydramine). It does, however, contain doxylamine which is also an antihistamine like Benadryl that can be used as a sleep aid.

Thanks for reaching out and please do so again anytime.

References

  • Diphenhydramine Monograph, PubChem
  • NyQuil Manufacturer Website, Vicks

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Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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