Does Metoprolol Cause Leg Swelling?

In our latest question and answer, the pharmacist discusses whether or not metoprolol, a beta blocker, can cause leg swelling.

Feb 01, 2018

KMW asked

My doctor recommended metoprolol for blood pressure. However, it causes swelling in my legs to uncomfortable levels. Is this a side effect that will disappear eventually?

Answer

Although uncommon, metoprolol (brand names Lopressor and Toprol) has been reported to cause peripheral edema (swelling due to the accumulation of fluids). Symptoms of peripheral edema generally occurs in the lower limbs (i.e. legs) and feet. 

Metoprolol - Leg Swelling Side Effect

Metoprolol is classified as a beta blocker and is used for a variety of indications including high blood pressure and angina. Metoprolol is considered to be fairly well tolerated but it is associated with certain side effects such as leg swelling (due to an accumulation of fluid).

The incidence of leg swelling on metoprolol is about 1% according to the prescribing information. Fortunately, this side effect is typically mild and temporary. It if is to occur, it generally happens at the onset of therapy but subsides completely over time.

It is important to be on the look out for edema or swelling if it occurs suddenly and you have been metoprolol therapy for a long period of time. While uncommon, metoprolol may precipitate heart failure in certain patients. Symptoms of heart failure include edema.

If symptoms of edema occur suddenly, and you have been taking metoprolol for a long period of time, be sure to contact your doctor for evaluation.

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