Does Amoxicillin Interact With Grapefruit?

In our latest question and answer, the pharmacist discusses whether or not grapefruit or grapefruit juice interacts with amoxicillin.

Jan 17, 2018

S99 asked

I accidentally mixed my amoxicillin 500 mg capsule with grapefruit juice. Is it still okay to take?


Amoxicillin does not have a listed or reported interaction with grapefruit juice and the combined use of both is considered to be safe.

Amoxicillin - Grapefruit Interaction

Grapefruit has notable interactions with many different medications. The interaction occurs via several different mechanisms including:

  • Inhibition of CYP3A metabolizing enzymes
  • Inhibition of organic anion-transporting polypeptides (OATPs)

Both grapefruit (the whole fruit) and the juice have been found to interact with medication. In fact, it can take just one grapefruit or as little as one cup (i.e. 8 ounces ounces) of grapefruit juice to cause a drug interaction. 

Making potential interactions worse, enzyme inhibition from grapefruit can last for over 24 hours, thus making separating medication and grapefruit/juice insignificant.

Fortunately, amoxicillin is not metabolized by anything that is affected by grapefruit/grapefruit juice, at least not significantly. They are considered safe to take together.

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