Can You Use Anti-Inflammatory Drugs With Difflam?

In our latest question and answer, the pharmacist discusses whether or not Difflam can be used with other anti-inflammatory medications.

Jan 31, 2018

beverly asked

Hi, my doctor recommended Difflam spray for a severe throat. Am I right in thinking you are best not taking more anti inflammatory medication as well because the spray contains anti-inflammatory properties?


Difflam throat spray contains benzydamine hydrochloride, which acts locally in the throat to relieve symptoms of irritation and inflammation. While benzydamine is classified as a NSAID (non steroidal anti-inflammatory drug), it doesn't appear work in the same way in terms of its mechanism of action.

It doesn't inhibit COX (cyclooxygenase) or lipooxygenase, two major factors in the inflammatory process. In addition, it doesn't appear to increase the risk of ulcer formation like many other NSAIDs (e.g. Ibuprofen and naproxen). As such, there are no listed or reported interactions with oral, systemic NSAID medications and may be safe to use with other anti-inflammatory medications.

Be sure to speak with your doctor regarding the best over the counter pain medicaiton for your specific condition. 

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