Pain girl asked
I just had an oxycodne at 1am for severe arthritis pain. Can I take no 5 hrs later a Tylenol and a benedryl to help me sleep
Answer
Tylenol (acetaminophen) and oxycodone may be safely taken together. There is no listed or reported interaction between the two medications.
In fact, oxycodone and Tylenol (acetaminophen) are combined in multiple prescription products including:
- Roxicet
- Endocet
- Tylox
- Percocet
If you have a prescription for oxycodone that does not contain Tylenol (acetaminophen), you may safely take it in addition to your oxycodone. If your prescription product already contains Tylenol (acetaminophen), you generally should not take any additional without first speaking with your doctor.
In regard to other oxycodone interactions, we wrote about combining it with Benadryl (diphenhydramine) in another article, which can be found here.
