Can You Take Mucinex And Sudafed Together?

In our latest question and answer, the pharmacists discusses whether or not Mucinex (guaifenesin) can be taken safely with Sudafed (pseudoephedrine).

Can You Take Mucinex And Sudafed Together?
Feb 06, 2018

Ashley asked

Can you take Mucinex (guaifenesin) and Sudafed (pseudoephedrine) together?


Mucinex And SudafedMucinex (guaifenesin), a commonly used over the counter expectorant, can be safely taken in combination with Sudafed (pseudoephedrine), a nasal decongestant. There is no listed or reported interaction between the two medications. In fact, there are a variety of over the counter products that combine both ingredients into a single product for ease of administration.

Taking Mucinex With Sudafed

Mucinex (guaifenesin) is classified as an expectorant and mucolytic. It loosens and thins phlegm and bronchial secretions, which in turn helps to ease expectoration. The less viscous secretions, due to Mucinex use, helps to increase the efficiency of our "mucociliary clearance mechanism", changing a dry, unproductive cough to a more productive one.

Sudafed (pseudoephedrine) is classified as a sympathomimetic nasal decongestant. It works by causing vasoconstriction, shrinking swollen nasal passages which helps to increase nasal airflow and reduce nasal congestion.

As mentioned above, Mucinex and Sudafed can be taken together and both are available in combination in a single product. Taking both Sudafed and Mucinex at the same time can often help to alleviate symptoms more than either product alone. In many cases, Sudafed can increases sinus drainage, potentially worsening chest congestion and post nasal drip. Combining Sudafed and Mucinex can help to reduce nasal congestion while also helping to relieve post nasal drip and chest congestion.

Examples of products that contain both Mucinex and Sudafed are:

  • Mucinex-D 12 Hour
  • Mucinex-D 24 Hour
  • Sunmark Mucus Relief D
  • Chest Congesion Relief D

You can feel safe using both Mucinex and Sudafed together, or using a single product that combines the two.

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