Can You Take Benadryl And Adderall Together?

In our latest question and answer, the pharmacist discusses whether or not it is safe to take Benadryl and Adderall together.

Can You Take Benadryl And Adderall Together?
Jun 21, 2020

Lynn asked

Can you take Benadryl with Adderall?

At a glance

  • Benadryl and Adderall may work against each other, Benadryl is sedating while Adderall is a stimulant.
  • Using Benadryl for an allergic reaction or short term should be OK to do.


Hi Lynn, thank you for your question.

Benadryl (or the generic diphenhydramine) and Adderall (or the generic amphetamine salts combo) is not the best combination to take routinely. To an extent, they work against each other.

Benadryl is a sedating histamine blocker. If you are taking your Adderall for something like narcolepsy or the stimulant effect, then the sedation from the Benadryl is going to work against it.

If you are taking Benadryl for an acute allergic reaction or to help with the symptoms of a cold, it should be safe to use Benadryl in the short term. Benadryl is the strongest antihistamine that you’ll find over the counter, so it should still be safe to use in the short term. If you are taking Benadryl for seasonal allergies, then I would recommend a non-sedating antihistamine like cetirizine (Zyrtec) or fexofenadine (Allegra) as these are both effective against seasonal allergies and won’t work against your Adderall.

If you are taking Benadryl for sleep, the Adderall may be lasting too long in your system and that might be causing issues sleeping. It may be appropriate to take it earlier in the day so that it’s worn off before bedtime. If you are already taking it early and it’s still in your system, it would probably be appropriate to talk to your doctor about a dosage adjustment or changing to an immediate release product (if you are on the XR capsules).

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