Can You Split Cialis 20mg Tablets With A Pill Splitter?

In our latest question and answer, the pharmacist discusses why Cialis tablets are not recommended to be cut or split.

Can You Split Cialis 20mg Tablets With A Pill Splitter?
Sep 21, 2019

John asked

Can I split my 20mg generic Cialis tablets with a pill splitter? Are they enteric coated or time-released?

At a glance

  • The manufacturer of Cialis states that the tablets cannot be split, cut or crushed. They must be dosed 'whole'.

Answer

Cialis Packaging

Cialis (tadalafil) is an interesting drug when it comes to whether or not it can safely be split.

It is neither enteric coated nor is it a time-release formulation, two attributes which, in most cases, means a drug should not be cut, split or chewed.

Splitting an enteric-coated tablet destroys the coating, which is there to protect it from dissolving in the stomach. Enteric coatings generally make a drug better tolerated, especially when it comes to gastrointestinal side effects.

Enteric coated aspirin, for example, is often better tolerated than non-enteric coated products.

Splitting a time-release drug is also something that shouldn't be done, since doing so will destroy the time-release mechanism, causing the entire drug to be delivered at once.

This can greatly increase the risk of overdose and associated side effects.

As mentioned, however, Cialis is not enteric-coated or time release, but, interestingly enough, is not recommended to be split. The prescribing information for the drug states this explicitly:

References
  1. Cialis Prescribing Information. Lilly
  2. Oral Dosage Forms That Should Not Be Crushed. ISMP
  3. Which drug for erectile dysfunction? Harvard Health

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