Can You Cut Or Split Fluconazole In Half?

In our latest question and answer, the pharmacist discusses whether or not fluconazole can safely be cut or split in half.

Can You Cut Or Split Fluconazole In Half?
Dec 21, 2017

Wraith asked

I pay out of pocket for my medication my insurance won't cover certain medications. Can I split a 200mg flucanazole pill so I can take half in the morning and half at night?


Yes, fluconazole can be safely cut or split in half without any reduced effectiveness of the medication. However, you should not change the directions your doctor has given you for your prescription. Splitting the 200 mg fluconazole tablet, to take 100 mg in the morning and evening, is perfectly acceptable if that is how your doctor has prescribed it.

As mentioned, cutting/splitting fluconazole (and other strengths) wail not negatively affect the medication. Cutting medication is often necessary for patients who have difficulty swallowing large tablets or need to take 'half' doses. 

Cutting fluconazole can sometimes be difficult however based on the tablet shape. Most manufacturers make the tablet as a trapezoid type shape (example below).

Fluconazole Tablet Shape

This non-symmetrical shape can make it difficult to perfectly split the medication into two equal halves. Due to this, careful use of a pill cutter is recommended versus using a knife. Be sure to situate the tablet appropriately in the pill cutter so it will cut the tablet into two equal halves.

Lastly, it is important that you take both halves of the medication as soon as possible and not store cut tablets for extended periods of time. Although fluconazole can be cut as mentioned above, split tablets no longer have a protective outer coating that most intact tablets have. This could make them more susceptible to moisture. Be sure to use split tablets as soon as you can and store the unused half in a moisture resistant container.

Fluconazole tablets, regardless of their shape, can be cut/split from all manufactures including:

  • Aurobindo
  • Barr
  • Dr. Reddy
  • Citron
  • Glenmark
  • Greenstone
  • Mylan 
  • Northstar
  • Sandoz
  • Teva
  • Ranbaxy

If you are having difficulty cutting the medication, fluconazole is also available in liquid formulations but those may not be as cost effective.

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