In our latest question and answer, our pharmacist discusses whether or not there is an interaction between Benadryl & Prozac.
Can I take diphenhydramine while taking Prozac?
There is no reported interaction between Prozac (fluoxetine) and Benadryl (diphenhydramine). They are considered to be safe to take together.
Having said that, both medications can cause sedation. Benadryl is well known to cause sedation and is often used as a nighttime sleep aid. Prozac can cause sedation in certain people, especially when therapy on it is just beginning. If Prozac is new for you, it would be recommended to take it in the evening until you know how it may affect you.
Aside from the possible additive sedative effect, you should not having any problems taking both Prozac and Benadryl together.