Amoxicillin Interacting With Flecainide

In our latest question and answer, we discuss whether or not there is an interaction between amoxicillin and flecainide.

Nov 10, 2017

Ginger snap asked

I am after 3 yrs of being on sotalol 40 mg two times daily and lisinipril 2.5 mg two times daily, and taking 2000 mg of amoxicillin before dental surgery, switching to flecanide acetate 50 mg two times daily. I also take a low dose of alprazalam when I get a svt attack, question I read there is a side effect with flecainide and amoxicillin... is this true? 


There are no reported interactions between flecainide, an antiarrhythmic and amoxicillin.  Both drugs were run through multiple drug references as well as the Pubmed database with no results.

Amoxicillin is available in combination with additional drugs that may interact with flecainide. One example is the combination of amoxicillin/clarithromycin and omeprazole. Amoxicillin, when taken as a sole agent however, does not have any documented interactions with flecainide.

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