Description

Simple

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Clinical

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Overview

Abexinostat has been used in trials studying the treatment of Sarcoma, Lymphoma, Leukemia, Lymphocytic, and Hodgkin Disease, among others. It is a novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity.

Pharmacology

Indication

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Pharmacodynamic

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Mechanism of action

Abexinostat is a novel histone deacetylase (HDAC) inhibitor. HDAC inhibitors target HDAC enzymes and inhibit the proliferation of cancer cells and induce cancer cell death, or apoptosis. Histone deacetylation is carried out by a family of related HDAC enzymes. Inhibition of these enzymes causes chan... Read more

Absorption

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Protein binding

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Volume of distribution

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Clearance

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Half life

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Route of elimination

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Toxicity

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Adverse Effects

Effect Regions Age Groups Incidences Evidence Type

Contraindications

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Food Interactions

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