Information currently not available.


Information currently not available.


Rauwolfia (Rauwolfia serpentina), also spelled _ravolphia_, is a medicinal plant in the milkweed family. The root of the plant is ground into a powder or sold in tablets or capsules. It is a compound commonly used in Asian medicine, which includes traditional Ayurvedic medicine native to India. The active ingredients in this drug are alkaloids and about 50 have been identified through various studies, although the primary psychoactive components appear to be reserpine, rescinnamine, and deserpidine [10].

This product was approved prior to Jan 1, 1982, but since, has been discontinued due to its propensity for leading to depression [8, 20]. Reserpine is derived from Rauwolfia serpentina, and was commonly used as an antihypertensive agent in the 1950s [12]. Rauwolfia serpentina is also commonly referred to as _Sarpaghanda_ [Read more



Rauwolfia alkaloids are indicated in the treatment of hypertension [6]. Rauwolfia alkaloids have been used for relief of symptoms in agitated psychotic states such as schizophrenia; however, use as antipsychotics and s... Read more


Reserpine is used to treat high blood pressure. It also is used to treat severe agitation in patients with mental disorders. Reserpine is in a class of medications called rauwolfia alkaloids. It works by slowing the activity of the nervous system, causing the heart rate to slow and the blood vessels... Read more

Mechanism of action

Reserpine is an adrenergic blocking agent used to treat mild to moderate hypertension via the disruption of norepinephrine vesicular storage. The antihypertensive actions of Reserpine are a result of its ability to deplete catecholamines from peripheral sympathetic nerve endings. These substances... Read more


Mean maximum plasma levels of plasma concentrations after 0.5 mg of Reserpine, administered as two 0.25 mg tablets or as an aqueous solution, peaked after 2.5 hours. The mean peak level was approximately 1.1 ng/ml. Bioavailability of Reserpine, has been reported to be approximately 50% [ Read more

Protein binding

Reserpine is extensively bound (95%) to plasma proteins [15].

Volume of distribution

Information currently not available.


Hepatically and renally [18].

Half life

After oral ingestion, an initial half-life of approximately 5 hours is followed by a terminal half-life of approximately 200 hours [16].

Route of elimination

The elimination of reserpine and its metabolites in the feces ranges from 30% after intramuscular administration to
about 60% after oral ingestion, primarily as unmetabolized reserpine, over a 4 day period after the
ingestionof 0.25 mg to 0.50 mg doses. Over the same time period, about 8% of the... Read more


Ld50: 390 mg/kg oral mouse [19].

Reserpine may increase gastric acid secretion and should be used with caution in patients with a history of gastroesophageal reflux disease (GERD) and peptic ulcer. It should also not be administere... Read more

Adverse Effects

Effect Regions Age Groups Incidences Evidence Type


Information currently not available.

Food Interactions

Information currently not available.