Description

Simple

Information currently not available.

Clinical

Information currently not available.

Overview

Aceclofenac is an oral non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties used to treat osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. It is reported to have a higher anti-inflammatory action or at least comparable effects than conventional NSAIDs in double-blind studies [2, 3, 5]. Aceclofenac potently inhibits the cyclo-oxygenase enzyme (COX) that is involved in the synthesis of prostaglandins, which are inflammatory mediators that cause pain, swelling, inflammation, and fever. Aceclofenac belongs to... Read more

Pharmacology

Indication

Aceclofenac is indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.

Pharmacodynamic

Aceclofenac is a NSAID that inhibits both isoforms of COX enzyme, a key enzyme involved in the inflammatory cascade. COX-1 enzyme is a constitutive enzyme involved in prostacyclin production and protective functions of gastric mucosa whereas COX-2 is an inducible enzyme involved in the production of... Read more

Mechanism of action

Through COX-2 inhibition, aceclofenac downregulates the production of various inflammatory mediators including prostaglandin E2 (PGE2), IL-1β, and TNF from the arachidonic acid (AA) pathway. Inhibition of IL-6 is thought to be mediated by diclofenac converted from aceclofenac [ Read more

Absorption

Aceclofenac is rapidly and completely absorbed from the gastrointestinal tract and circulates mainly as unchanged drug following oral administration. Peak plasma concentrations are reached around 1.25 to 3 hours post-ingestion, and the drug penetrates into the synovial fluid where the concentration... Read more

Protein binding

It is reported to be highly protein-bound (>99%) [11].

Volume of distribution

The volume of distribution is approximately 25 L [11].

Clearance

The mean clearance rate is approximately 5 L/h [ Read more

Half life

The mean plasma elimination half-life is approximately 4 hours [11].

Route of elimination

The main route of elimination is via the urine where the elimination accounts for 70-80% of clearance of the drug [2]. Approxi... Read more

Toxicity

Some common adverse effects include gastro-intestinal disorders (dyspepsia, abdominal pain, nausea), rash, ruber, urticaria, symptoms of enuresis, headache, dizziness, and drowsiness [12... Read more

Adverse Effects

Effect Regions Age Groups Incidences Evidence Type
Headache US
Varying Reports
Drowsiness US
Varying Reports
Symptoms of enuresis US
Varying Reports
Dizziness US
Varying Reports
Rash US
Varying Reports
Urticaria US
Varying Reports
Abdominal Pain US
Varying Reports
Nausea US
Varying Reports
Dyspepsia US
Varying Reports

Contraindications

  • Regions: US
  • Patient Conditions:
      • Name: Active peptic ulcer
      • Drugbank Id: DBCOND0107771
      • Modification Of:
        • Condition Status: active
        • Base:
          • Name: Peptic ulcer
          • Drugbank Id: DBCOND0120192
  • Regions: US
  • Patient Conditions:
      • Name: Asthma
      • Drugbank Id: DBCOND0013565
  • Hypersensitivity:
    • diclofenac
    • diclofenac analogues
  • Regions: US

Food Interactions

Take with or without food.