Description

Simple

An injection used to treat attacks of abdominal pain, weakness, seizures, and a fast heartbeat that happen in some women around or during menstrual cycles that are called acute intermittent porphyrias (AIP).

Clinical

An iron-containing porphyrin injection used for the relief of recurrent attacks of acute intermittent porphyria (AIP) associated with the menstrual cycle when carbohydrate therapy is not effective.

Overview

Hemin (trade name Panhematin) is an iron-containing porphyrin. More specifically, it is protoporphyrin IX containing a ferric iron ion (heme B) with a chloride ligand.

Pharmacology

Indication

Used in the management of porphyria attacks, particularly in acute intermittent porphyria.

Pharmacodynamic

Information currently not available.

Mechanism of action

Information currently not available.

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Effect Regions Age Groups Incidences Evidence Type
Headache US
  • Kind: experimental
    • Percent: 3-9%
  • Clinical Trial
    Pyrexia US
  • Kind: experimental
    • Percent: 3-5%
  • Clinical Trial
    Phlebitis US
  • Kind: experimental
    • Percent: 3-4%
  • Clinical Trial
    Catheter-related complication US
  • Kind: experimental
    • Percent: 2-4%
  • Clinical Trial
    Rash US
  • Kind: experimental
    • Percent: 2%
  • Clinical Trial
    Cellulitis US
  • Kind: experimental
    • Percent: 1-2%
  • Clinical Trial
    Thrombocytopenia US
    Post Marketing
    Infusion-related anaphylactoid reaction US
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    Hypersensitivity reactions US
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    Infusion site reactions US
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    Injection site venous thrombosis US
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    Prolonged prothrombin time US
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    Coagulopathy US
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    Hemolysis US
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    Prolonged partial thromboplastin time US
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    Serum ferritin increased US
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    Iron Overload US
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    Pain US
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    Erythema US
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    Extravasation US
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    Bleeding US
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    Contraindications

    Information currently not available.

    Food Interactions

    Information currently not available.