Description

Simple

A nutrient commonly found in a wide variety of multivitamins.

Clinical

A vitamin used to correct vitamin C deficiency and to increase the intestinal absorption of iron.

Overview

A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.

Pharmacology

Indication

Used to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent.

Pharmacodynamic

Ascorbic Acid (vitamin C) is a water-soluble vitamin indicated for the prevention and treatment of scurvy, as ascorbic acid deficiency results in scurvy. Collagenous structures are primarily affected, and lesions develop in bones and blood vessels. Administration of ascorbic acid completely reverses... Read more

Mechanism of action

In humans, an exogenous source of ascorbic acid is required for collagen formation and tissue repair by acting as a cofactor in the posttranslational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Ascorbic acid is reversibly oxidized to dehydroascorbic acid... Read more

Absorption

70% to 90%

Protein binding

25%

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

16 days (3.4 hours in people who have excess levels of vitamin C)

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Effect Regions Age Groups Incidences Evidence Type
Severe Hemolysis US
Varying Reports
Chronic Oxalate Nephropathy US
Varying Reports
Acute oxalate nephropathy US
Varying Reports
Faintness/fainting US
Varying Reports
Lethargy US
Varying Reports
Nausea US
Varying Reports
Flushing US
Varying Reports
Dizziness US
Varying Reports
Headache US
Varying Reports
Swelling US
Varying Reports
Administration site reactions US
Varying Reports
Pain US
Varying Reports

Contraindications

Information currently not available.

Food Interactions

Avoid multivalent ions. Do not infuse with elemental compounds that can be reduced, such as copper.