Description

Simple

A medication used in emergencies to increase blood pressure.

Clinical

A peptide hormone used to increase blood pressure in patients with vasodilatory shock who are resistant to fluid and catecholamine therapy.

Overview

Antidiuretic hormone, also known as vasopressin, is a nine amino acid peptide secreted from the posterior pituitary. Antidiuretic hormone binds to receptors in the distal or collecting tubules of the kidney and promotes reabsorbtion of water back into the circulation

Pharmacology

Indication

For the treatment of enuresis, polyuria, diabetes insipidus, polydipsia and oesophageal varices with bleeding

Pharmacodynamic

Vasopressin is an antidiuretic hormone indicated for the prevention and treatment of postoperative abdominal distention, in abdominal roentgenography to dispel interfering gas shadows, and in diabetes insipidus. Vasopressin can cause contraction of smooth muscle of the gastrointestinal tract and of... Read more

Mechanism of action

Vasopressin acts on three different receptors, vasopressin receptor V1a (which initiates vasoconstriction, liver gluconeogenesis, platelet aggregation and release of factor VIII), vasopressin receptor V1b (which mediates corticotrophin secretion from the pituitary) and vasopressin receptor V2 which... Read more

Absorption

Information currently not available.

Protein binding

1%

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

10-20 minutes

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Effect Regions Age Groups Incidences Evidence Type
Abdominal Cramps US
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Nausea US
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Vomiting US
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Passage of gas US
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Tremor US
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Vertigo US
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Pounding sensation in head US
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Bronchoconstriction US
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Sweating US
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Urticaria US
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Water Intoxication US
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Anaphylaxis US
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Circumoral pallor US
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Cardiac Arrest US
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Decreased cardiac output US
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Arrhythmias US
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Myocardial Ischemia US
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Angina US
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Gangrene US
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Peripheral vasoconstriction US
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Contraindications

Information currently not available.

Food Interactions

Avoid alcohol.